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李延伟
作者:   时间:2018-02-01   点击数:

李延伟 博士

博士 助理研究员 硕士生导师

通讯地址:山东省济南市山大南路27号

办公电话:0531-88369787

E-mail:lyw@sdu.edu.cn

个人简介:

工作经历

2014/07-至今,山东大学,环境研究院,助理研究员

2015/11-2016/11,加州大学洛杉矶分校,化学与生物化学系,访问学者,合作导师:Kendall Houk教授

教育背景

2009/09-2014/06,山东大学,环境研究院,博士,导师:张庆竹教授

2005/09-2009/06,山东大学,化学与化工学院,学士

学术兼职:

现任职务:

研究方向:

  1. 典型环境污染物与人体关键大分子(DNA、蛋白质等)的相互作用机理研究

  2. 微生物体内关键酶对持久性环境污染物的降解机理研究

其他信息:


主持承担的科研项目:

1.国家自然科学基金青年项目,项目编号:21507073,负责人

2.山东省自然科学基金培育基金,项目编号:ZR2015PB002,负责人

3.国家自然科学基金重点项目专项(子课题4),项目编号:91644214,子课题负责人

4.中国博士后科学基金特别资助,项目编号:2016T90635,负责人

5.中国博士后科学基金面上项目一等资助,项目编号:2015M570594,负责人

6.山东省博士后创新项目专项一等资助,项目编号:201501009,负责人

7.山东大学基本科研业务费资助项目,项目编号:2015GN007,负责人

8.国家自然科学基金面上项目,项目编号:21577082,参与

9.国家自然科学基金面上项目,编号:21177077,参与(已结题)

10.山东大学自主创新基金,项目编号:2012JC030,参与(已结题)


论文与著作:

(1)Yanwei Li, Lei Bao, RuimingZhang,Xiaowen Tang, Qingzhu Zhang*, Wenxing Wang, Insights into theerrorbypass of 1-Nitropyrene DNA adduct by DNA polymerase i: A QM/MM study,Chemical Physics Letters, 2017, 686,12−17.(IF=1.815)

(2)Chengqiang Wang#,Yanwei Li#, Chenxi Qiu#, Shihao Wang, JinjinMa, YuShen, Qingzhu Zhang, Binghai Du, Yanqin Ding*and Xiaoming Bao*, Identificationof Important Amino Acids in Gal2p for Improving the L-arabinoseTransport andMetabolism in Saccharomyces cerevisiae,Frontiers in Microbiology, 2017, 8, 1391. (#为共一作者,IF=4.076)

(3)Yanwei Li,Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang,Catalyticmechanism of C-F bond cleavage: insights from QM/MM analysis offluoroacetatedehalogenase,Catalysis Science & Technology, 2016,6(1): 73-80. (封面文章, IF=5.773)

(4)Yanwei Li, Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang,How ManyConformations of Enzymes Should Be Sampled for DFT/MM Calculations? ACase Studyof Fluoroacetate Dehalogenase,InternationalJournalof Molecular Sciences, 2016, 17(8), 1372. (IF=3.226)

(5)Yanwei Li, Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang,Insight intothe Catalytic Mechanism of meta-Cleavage Product Hydrolase BphD: AQuantumMechanics/Molecular Mechanics Study,RSC Advances, 2015,5(82):66591-66597. (IF=3.108)

(6)Yanwei Li, Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang,Insightsinto the Catalytic Mechanism of Chlorophenol 4-Monooxygenase: AQuantumMechanics/Molecular Mechanics Study,RSC Advances, 2015,5(18),13871-13877. (IF=3.108)

(7)Yanwei Li, Xiangli Shi , Qingzhu Zhang*, Jingtian Hu, JianminChen, andWenxing Wang, Computational Evidence for the Detoxifying Mechanism ofEpsilonClass Glutathione Transferase Toward the Insecticide DDT,EnvironmentalScience& Technology, 2014, 48 (9): 5008-5016. (IF=6.198)

(8)Yanwei Li, Lei Ding, Qingzhu Zhang*, Wenxing Wang, MD and QM/MMstudy oncatalytic mechanism of a FAD-dependent enzyme ORF36: For nitrosugarbiosynthesis,Journal of Molecular Graphics & Modelling, 2013,44:9-16. (IF=1.754)

(9)Yanwei Li, Xiaomin Sun, Likai Du, Qingzhu Zhang*, Wenxing Wang,QM/MM Studyon the Spontaneous Reactivation Mechanismof(±)Methamidophos-inhibited-acetylcholinesterase,ComputationalandTheoretical Chemistry, 2012, 980: 108-114. (IF=1.549)

(10)Yanwei Li, Likai Du, Yueming Hu, Xiaomin Sun, Jingtian Hu*,TheoreticalStudy on the Aging and Reactivation MechanismofTabun-inhibited-acetylcholinesterase by Using QM/MM Method,CanadianJournalof Chemistry. 2012, 90(4): 376-383. (IF=1.080)

(11)Zhongfei Ren, Xing Xu*, Baoyu Gao*,Yanwei Li, Jian Kong, Yanan Shang, Wen Song, Qingzhu Zhang, Captureof perchlorateby a surface-modified bio-sorbent and its bioregenerationproperties:Adsorption, computations and biofouling,Chemosphere,2017, 185, 152-161. (IF=4.208)

(12)Zhongfei Ren , Xing Xu*, Shutao Qi,Yanwei Li, Baoyu Gao, Wen song, Peng Jiang, Uptake of phosphate and Cr(VI)byamine-functionalized Chinese reed: Considering the computations andcharacteristicsanalysis,Journal of theTaiwan Instituteof Chemical Engineers, 2017, 72, 85-94. (IF=4.217)

(13)Elizabeth L. Noey, Zhongyue Yang,Yanwei Li,Hannah Yu, Rachel N. Richey, Jeremy M. Merritt, Douglas P. Kjell, andK. N. Houk*,Origins of regioselectivity in the Fischer indole synthesisof a selectiveandrogen receptor modulator,JournalofOrganic Chemistry,2017, 82, 5904−5909. (IF=4.849)

(14)Xiaowen Tang; Ruiming Zhang;Yanwei Li;QingzhuZhang*; Wenxing Wang, Enantioselectivity of haloalkanedehalogenase LinBon the degradation of 1,2-dichloropropane: A QM/MM study,Bioorganic Chemistry, 2017, 73, 16-23. (IF=3.231)

(15)Peiyuan Yu#, Zhongyue Yang#, Yong Liang,Xin Hong,Yanwei Li, Kendall Houk*, Distortion-ControlledReactivity andMolecular Dynamics of Dehydro-Diels-Alder Reactions,Journal of the American Chemical Society,2016, 138(26), 8247-8252.(#为共一作者,IF=13.858)

(16)Chengqiang Wang#, Xiaoming Bao#,Yanwei Li,Chunlei Jiao, Jin Hou, Qingzhu Zhang, Weixin Zhang, Weifeng Liu, YuShen*,Cloning and characterization of heterologous transporters inSaccharomycescerevisiae and identification of important amino acids for xyloseutilization,MetabolicEngineering, 2015, 30: 79-88. (#为共一作者,IF=8.142)

(17)Kuangcai Chen, Hua Jin,Yanwei Li, Junyoung Shin, Jae-Min Lim, Yong-IllLee,Isomeric quantification of O-diglycosyl flavonoids by a complex-freekineticmethod using ESI/QToF mass spectrometry.Microchemical Journal,2014,117, 46-51. (IF=3.034)


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