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李延伟
作者:   时间:2018-02-01   点击数:

李延伟

博士 副教授 硕士生导师

通讯地址:山东省济南市山大南路27号

办公电话:0531-88369787

E-mail:lyw@sdu.edu.cn

个人简介:

工作经历

2017/09-至今,山东大学,环境研究院,副教授

2015/11-2016/11,加州大学洛杉矶分校,化学与生物化学系,访问学者,合作导师:Kendall Houk教授

2014/07-2017/09,山东大学,环境研究院,助理研究员

教育背景

2009/09-2014/06,山东大学,环境研究院,博士,导师:张庆竹教授

2005/09-2009/06,山东大学,化学与化工学院,学士

学术兼职:

现任职务:

研究方向:

微生物体内关键酶对持久性环境污染物的降解机理研究

典型环境污染物与人体关键大分子(DNA、蛋白质等)的相互作用机理研究

其他信息:

 

主持承担的科研项目:

1.国家自然科学基金青年项目,项目编号:21507073,负责人

2.山东省自然科学基金培育基金,项目编号:ZR2015PB002,负责人

3.国家自然科学基金重点项目专项(子课题4),项目编号:91644214,子课题负责人

4.中国博士后科学基金特别资助,项目编号:2016T90635,负责人

5.中国博士后科学基金面上项目一等资助,项目编号:2015M570594,负责人

6.山东省博士后创新项目专项一等资助,项目编号:201501009,负责人

7.山东大学基本科研业务费资助项目,项目编号:2015GN007,负责人(已结题)

8.国家自然科学基金面上项目,项目编号:21577082,参与

9.国家自然科学基金面上项目,编号:21177077,参与(已结题)

10.山东大学自主创新基金,项目编号:2012JC030,参与(已结题)

 

论文与著作:

 (1) Zhongyue Yang#, Song Yang#, Peiyuan Yu#, Yanwei Li#(共同第一), Charles Doubleday, Jiyong Park, Ashay Patel, Byung-sun Jeon, William K. Russell, Hung-wen Liu, David H. Russell, and Kendall N. Houk*, Influence of water and enzyme SpnF on the dynamics and energetics of the ambimodal [6+4]/[4+2] cycloaddition, Proceedings of the National Academy of Sciences of the United States of America, 2018, 115, E848-E855. (IF=9.661)

(2) Jianxin Guan#, Chuancheng Jia#, Yanwei Li#(共同第一), Zitong Liu#, Jinying Wang, Zhongyue Yang, Chunhui Gu, Dingkai Su, Kendall N. Houk*, Deqing Zhang*, and Xuefeng Guo*, Direct single-molecule dynamic detection of chemical reactions. Science Advances, 2018, 4, eaar2177. (Highlighted by C&EN)

(3) Yanwei Li, Lei Bao, Ruiming Zhang, Xiaowen Tang, Qingzhu Zhang*, Wenxing Wang, Insights into the error bypass of 1-Nitropyrene DNA adduct by DNA polymerase i: A QM/MM study, Chemical Physics Letters, 2017, 686, 12−17. (IF=1.815)

(4) Chengqiang Wang#, Yanwei Li#(共同第一), Chenxi Qiu#, Shihao Wang, Jinjin Ma, Yu Shen, Qingzhu Zhang, Binghai Du, Yanqin Ding* and Xiaoming Bao*, Identification of Important Amino Acids in Gal2p for Improving the L-arabinose Transport and Metabolism in Saccharomyces cerevisiae, Frontiers in Microbiology, 2017, 8, 1391. (IF=4.076)

(5) Yanwei Li, Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang, Catalytic mechanism of C-F bond cleavage: insights from QM/MM analysis of fluoroacetate dehalogenase, Catalysis Science & Technology, 2016, 6(1): 73-80. (期刊封面, IF=5.773)

(6) Yanwei Li, Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang, How Many Conformations of Enzymes Should Be Sampled for DFT/MM Calculations? A Case Study of Fluoroacetate Dehalogenase, International Journal of Molecular Sciences, 2016, 17(8), 1372. (IF=3.226)

(7) Yanwei Li, Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang, Insight into the Catalytic Mechanism of meta-Cleavage Product Hydrolase BphD: A Quantum Mechanics/Molecular Mechanics Study, RSC Advances, 2015, 5(82): 66591-66597. (IF=3.108)

(8) Yanwei Li, Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang, Insights into the Catalytic Mechanism of Chlorophenol 4-Monooxygenase: A Quantum Mechanics/Molecular Mechanics Study, RSC Advances, 2015, 5(18), 13871-13877. (IF=3.108)

(9) Yanwei Li, Xiangli Shi , Qingzhu Zhang*, Jingtian Hu, Jianmin Chen, and Wenxing Wang, Computational Evidence for the Detoxifying Mechanism of Epsilon Class Glutathione Transferase Toward the Insecticide DDT, Environmental Science & Technology, 2014, 48 (9): 5008-5016. (IF=6.198)

(10) Yanwei Li, Lei Ding, Qingzhu Zhang*, Wenxing Wang, MD and QM/MM study on catalytic mechanism of a FAD-dependent enzyme ORF36: For nitro sugar biosynthesis, Journal of Molecular Graphics & Modelling, 2013, 44: 9-16. (IF=1.754)

(11) Yanwei Li, Xiaomin Sun, Likai Du, Qingzhu Zhang*, Wenxing Wang, QM/MM Study on the Spontaneous Reactivation Mechanism of (±)Methamidophos-inhibited-acetylcholinesterase, Computational and Theoretical Chemistry, 2012, 980: 108-114. (IF=1.549)

(12) Yanwei Li, Likai Du, Yueming Hu, Xiaomin Sun, Jingtian Hu*, Theoretical Study on the Aging and Reactivation Mechanism of Tabun-inhibited-acetylcholinesterase by Using QM/MM Method, Canadian Journal of Chemistry. 2012, 90(4): 376-383. (IF=1.080)

 

(13) Likai Du*, Fang Liu, Yanwei Li, Zhongyue Yang, Qingzhu Zhang, Chaoyuan Zhu, Jun Gao*. Dioxygen Activation by Iron Complexes: The Catalytic Role of Intersystem Crossing Dynamics for a Heme-Related Model. Journal of Physical Chemistry C, 2018, 122, 5, 2821-2831. (IF=4.536)

(14) Elizabeth L. Noey, Zhongyue Yang, Yanwei Li, Hannah Yu, Rachel N. Richey, Jeremy M. Merritt, Douglas P. Kjell, and K. N. Houk*, Origins of regioselectivity in the Fischer indole synthesis of a selective androgen receptor modulator, Journal of Organic Chemistry, 2017, 82, 5904−5909. (IF=4.849)

(15) Zhongfei Ren, Xing Xu*, Baoyu Gao*, Yanwei Li, Jian Kong, Yanan Shang, Wen Song, Qingzhu Zhang, Capture of perchlorate by a surface-modified bio-sorbent and its bioregeneration properties: Adsorption, computations and biofouling, Chemosphere, 2017, 185, 152-161. (IF=4.208)

(16) Zhongfei Ren , Xing Xu*, Shutao Qi, Yanwei Li, Baoyu Gao, Wen song, Peng Jiang, Uptake of phosphate and Cr(VI) by amine-functionalized Chinese reed: Considering the computations and characteristics analysis, Journal of the Taiwan Institute of Chemical Engineers, 2017, 72, 85-94. (IF=4.217)

(17) Xiaowen Tang; Ruiming Zhang; Yanwei Li; Qingzhu Zhang*; Wenxing Wang, Enantioselectivity of haloalkane dehalogenase LinB on the degradation of 1,2-dichloropropane: A QM/MM study, Bioorganic Chemistry, 2017, 73, 16-23. (IF=3.231)

(18) Peiyuan Yu#, Zhongyue Yang#, Yong Liang, Xin Hong, Yanwei Li, Kendall Houk*, Distortion-Controlled Reactivity and Molecular Dynamics of Dehydro-Diels-Alder Reactions, Journal of the American Chemical Society, 2016, 138(26), 8247-8252. (IF=13.858)

(19) Chengqiang Wang#, Xiaoming Bao#, Yanwei Li, Chunlei Jiao, Jin Hou, Qingzhu Zhang, Weixin Zhang, Weifeng Liu, Yu Shen*, Cloning and characterization of heterologous transporters in Saccharomyces cerevisiae and identification of important amino acids for xylose utilization, Metabolic Engineering, 2015, 30: 79-88. (IF=8.142)

(20) Kuangcai Chen, Hua Jin, Yanwei Li, Junyoung Shin, Jae-Min Lim, Yong-Ill Lee, Isomeric quantification of O-diglycosyl flavonoids by a complex-free kinetic method using ESI/QToF mass spectrometry. Microchemical Journal, 2014, 117, 46-51. (IF=3.034)


 

 

 

 

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